Glutathione neutralizes free radicals and detoxifies harmful substances, protecting our cells from oxidative stress
Oxidant species and electrophiles are able to increase the transcription of both the modulatory and catalytic subunits (Shi et al., 1994
An array of studies has demonstrated a significant correlation between sorafenib resistance and the onset of ferroptosis in hepatocytes, with multiple key molecules of the ferroptosis pathway implicated in the initiation, progression, and prognosis of HCC
These findings, along with the fact that the lung can normally maintain GSH for long periods even with the oxidant burden of CS, lend credence to the theory that disease symptoms could arise when adaptive responses fail or are dysfunctional
cDNA synthesis was performed using the iScript cDNA Synthesis Kit (1708891, Bio-Rad, USA), and 1 g of RNA obtained after DNase treatment was used for each sample